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1

Glutamine and glutamate—their central role in cell metabolism and function

Philip Newsholme, Joaquim Procopio, Manuela Maria Ramos Lima, Tania Cristina Pithon-Curi, Rui Curi

Journal:

Cell Biochemistry and Function

Year:

2003

Language:

english

File:

PDF, 210 KB

english, 2003

2

Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome

Bridgeman, Stephanie C., Northrop, Wendy, Melton, Phillip E., Ellison, Gaewyn C., Newsholme, Philip, Mamotte, Cyril D.S.

Journal:

Pharmacological Research

Year:

2020

File:

PDF, 1.23 MB

2020

3

Cancer stem cell metabolism: a potential target for cancer therapy

Deshmukh, Abhijeet, Deshpande, Kedar, Arfuso, Frank, Newsholme, Philip, Dharmarajan, Arun

Journal:

Molecular Cancer

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

4

Effects of vitamin D on primary human skeletal muscle cell proliferation, differentiation, protein synthesis and bioenergetics

Romeu Montenegro, Karina, Maron Carlessi, Rodrigo, Fernandes Cruzat, Vinicius, Newsholme, Philip

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 790 KB

english, 2019

5

The effect of fatty acids on leucocyte subsets and proliferation in rat whole blood

Parveen Yaqoob, Eric A. Newsholme, Philip C. Calder

Journal:

Nutrition Research

Year:

1995

Language:

english

File:

PDF, 830 KB

english, 1995

6

Insulinotropic properties of whey protein hydrolysates and impact of peptide fractionation on insulinotropic response

Nongonierma, Alice B., Gaudel, Celine, Murray, Brian A., Flynn, Sarah, Kelly, Phillip M., Newsholme, Philip, FitzGerald, Richard J.

Journal:

International Dairy Journal

Year:

2013

Language:

english

File:

PDF, 444 KB

english, 2013

7

The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production

Krause, Mauricio, Rodrigues-Krause, Josianne, OâHagan, Ciara, Medlow, Paul, Davison, Gareth, Susta, Davide, Boreham, Colin, Newsholme, Philip, OâDonnell, Mark, Murphy, Colin, Vito, Giuseppe

Journal:

European Journal of Applied Physiology

Year:

2014

Language:

english

File:

PDF, 391 KB

english, 2014

8

Amino acid supplementation and impact on immune function in the context of exercise

Cruzat, Vinicius, Krause, Maurício, Newsholme, Philip

Journal:

Journal of the International Society of Sports Nutrition

Year:

2014

Language:

english

File:

PDF, 1.28 MB

english, 2014

9

Plasma amino acid concentrations in the overtraining syndrome

PARRY-BILLINGS, MARK, BUDGETT, RICHARD, KOUTEDAKIS, YIANNIS, BLOMSTRAND, EVA, BROOKS, STEVEN, WILLIAMS, CLYDE, CALDER, PHILIP C., PILLING, SIAN, BAIGRIE, ROBERT, NEWSHOLME, ERIC A.

Journal:

Medicine & Science in Sports & Exercise

Year:

1992

File:

PDF, 565 KB

1992

10

Gut associated bacteria are critical to metabolism, inflammation and health

Newsholme, Philip, Homem de Bittencourt, Paulo Ivo

Journal:

Current Opinion in Clinical Nutrition & Metabolic Care

Year:

2016

Language:

english

File:

PDF, 250 KB

english, 2016

11

Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production

Calder, Philip C., Newsholme, Eric A.

Journal:

Clinical Science

Year:

1992

Language:

english

File:

PDF, 755 KB

english, 1992

12

Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?2

Newsholme, Philip

Journal:

Journal of Nutrition

Year:

2001

Language:

english

File:

PDF, 241 KB

english, 2001

13

Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n−3 or n−6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y

Thies, Frank, Nebe-von-Caron, Gerhard, Powell, Jonathan R, Yaqoob, Parveen, Newsholme, Eric A, Calder, Philip C

Journal:

American Journal of Clinical Nutrition

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

14

Unsaturated fatty acids suppress interleukin-2 production and transferrin receptor expression by concanavalin A-stimulated rat Iymphocytes

Calder, Philip C., Newsholme, Eric A.

Journal:

Mediators of Inflammation

Year:

1992

Language:

english

File:

PDF, 2.20 MB

english, 1992

15

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

Cruzat, Vinicius, Macedo Rogero, Marcelo, Noel Keane, Kevin, Curi, Rui, Newsholme, Philip

Journal:

Year:

2018

Language:

english

File:

PDF, 3.31 MB

english, 2018

16

The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies

Calton, Emily K., Keane, Kevin N., Newsholme, Philip, Soares, Mario J., Polyak, Stephen J

Journal:

Year:

2015

Language:

english

File:

PDF, 2.42 MB

english, 2015

17

The effects of a combined bodyweight-based and elastic bands resistance training, with or without protein supplementation, on muscle mass, signaling and heat shock response in healthy older people

Krause, Mauricio, Crognale, Domenico, Cogan, Karl, Contarelli, Serena, Egan, Brendan, Newsholme, Philip, De Vito, Giuseppe

Journal:

Experimental Gerontology

Year:

2019

Language:

english

File:

PDF, 1.09 MB

english, 2019

18

Tribute to Dr LFBP Costa Rosa, 1964–2005

Rui Curi, Philip Newsholme

Journal:

Cell Biochemistry and Function

Year:

2005

Language:

english

File:

PDF, 30 KB

english, 2005

19

Effects of short chain fatty acids on effector mechanisms of neutrophils

Marco A. R. Vinolo, Elaine Hatanaka, Rafael H. Lambertucci, Philip Newsholme, Rui Curi

Journal:

Cell Biochemistry and Function

Year:

2009

Language:

english

File:

PDF, 255 KB

english, 2009

20

Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid

Hilton Kenji Takahashi, Tavane David Cambiaghi, Augusto Ducati Luchessi, Sandro Massao Hirabara, Marco Aurelio Ramirez Vinolo, Philip Newsholme, Rui Curi

Journal:

Journal of Cellular Physiology

Year:

2012

Language:

english

File:

PDF, 635 KB

english, 2012

21

Effect of fatty acids on the proliferation of concanavalin a-stimulated rat lymph node lymphocytes

Philip C. Calder, Jane A. Bond, Samantha J. Bevan, Simon V. Hunt, Eric A. Newsholme

Journal:

International Journal of Biochemistry

Year:

1987

Language:

english

File:

PDF, 1.26 MB

english, 1987

22

Maximal activities of key enzymes of glutaminolysis, glycolysis, Krebs cycle and pentose-phosphate pathway of several tissues in mature and aged rats

Anelisa Ferreira De Almeida, Rui Curi, Philip Newsholme, Eric A. Newsholme

Journal:

International Journal of Biochemistry

Year:

1989

Language:

english

File:

PDF, 395 KB

english, 1989

23

Inhibition of natural killer cell activity by dietary lipids

Parveen Yaqoob, Eric A. Newsholme, Philip C. Calder

Journal:

Immunology Letters

Year:

1994

Language:

english

File:

PDF, 626 KB

english, 1994

24

Characterization of lipoprotein composition in rats fed different dietary lipids and of the effects of lipoproteins upon lymphocyte proliferation

Nicola M. Jeffery, Parveen Yaqoob, David Wiggins, Geoffrey F. Gibbons, Eric A. Newsholme, Philip C. Calder

Journal:

The Journal of Nutritional Biochemistry

Year:

1996

Language:

english

File:

PDF, 1.66 MB

english, 1996

25

Oleic, linoleic and γ-linolenic acids increase ROS production by fibroblasts via NADPH oxidase activation

Elaine Hatanaka, Alexandre Dermargos, Aparecida Emiko Hirata, Angelo Rafael Carpinelli, Philip Newsholme, Hugo Aguirre Armelin, Rui Curi

Journal:

Chemistry and Physics of Lipids

Year:

2007

Language:

english

File:

PDF, 55 KB

english, 2007

26

A proteomic analysis of the functional effects of fatty acids in NIH 3T3 fibroblasts

Juliana Magdalon, Elaine Hatanaka, Talita Romanatto, Hosana G Rodrigues, Wilson MT Kuwabara, Caitriona Scaife, Philip Newsholme, Rui Curi

Journal:

Lipids in Health and Disease

Year:

2011

Language:

english

File:

PDF, 543 KB

english, 2011

27

Genes regulated by arachidonic and oleic acids in Raji cells

Rozangela Verlengia, Renata Gorjão, Carla Cristine Kanunfre, Silvana Bordin, Thais Martins de Lima, Philip Newsholme, Rui Curi

Journal:

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

28

Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells

Rozangela Verlengia, Renata Gorjão, Carla Cristine Kanunfre, Silvana Bordin, Thais Martins de Lima, Edgair Fernandes Martins, Philip Newsholme, Rui Curi

Journal:

Year:

2004

Language:

english

File:

PDF, 242 KB

english, 2004

29

Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism

Lorraine Brennan, Chandralal Hewage, J. P. G. Malthouse, Neville H. McClenaghan, Peter R. Flatt, Philip Newsholme

Journal:

Year:

2006

Language:

english

File:

PDF, 238 KB

english, 2006

30

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

Josianne Rodrigues-Krause, Mauricio Krause, C. O’Hagan, Giuseppe De Vito, Colin Boreham, Colin Murphy, Philip Newsholme, Gerard Colleran

Journal:

Cell Stress and Chaperones

Year:

2012

Language:

english

File:

PDF, 281 KB

english, 2012

31

Propionate regulates lymphocyte proliferation and metabolism

Rui Curi, Jane A. Bond, Philip C. Calder, Eric A. Newsholme

Journal:

General Pharmacology: The Vascular System

Year:

1993

Language:

english

File:

PDF, 637 KB

english, 1993

32

Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation

Yvonne M O’Dowd, Jamel El-Benna, Axel Perianin, Philip Newsholme

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 206 KB

english, 2004

33

Tribute to Dr. L. F. B. P. Costa Rosa, 1964–2005

Rui Curi, Philip Newsholme

Journal:

Year:

2006

Language:

english

File:

PDF, 42 KB

english, 2006

34

Identification of a novel complement-dependent serum-elicited inward current in the Xenopus oocyte provoking Ca2+ influx and subsequent activation of Cl− channels

Philip Newsholme, Michael L.J. Ashford, C.Nicholas Hales

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 374 KB

english, 1999

35

The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal

Eric A. Newsholme, Philip C. Calder

Journal:

Year:

1997

Language:

english

File:

PDF, 445 KB

english, 1997

36

COMPARISON OF CYTOKINE PRODUCTION IN CULTURES OF WHOLE HUMAN BLOOD AND PURIFIED MONONUCLEAR CELLS

Parveen Yaqoob, Eric A. Newsholme, Philip C. Calder

Journal:

Year:

1999

Language:

english

File:

PDF, 211 KB

english, 1999

37

Influence of cell culture conditions on diet-induced changes in lymphocyte fatty acid composition

Parveen Yaqoob, Eric A. Newsholme, Philip C. Calder

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1995

Language:

english

File:

PDF, 714 KB

english, 1995

38

Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat

Parveen Yaqoob, Emma J. Sherrington, Nicola M. Jeffery, Peter Sanderson, David J. Harvey, Eric A. Newsholme, Philip C. Calder

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.41 MB

english, 1995

39

In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype

Donal J. O’Gorman, Obada Yousif, Gordon Dixon, Siobhan McQuaid, Elaine Murphy, Yousif Rahman, Declan Gasparro, Giovanni Pacini, Philip Newsholme, John J. Nolan

Journal:

Diabetes Research and Clinical Practice

Year:

2008

Language:

english

File:

PDF, 275 KB

english, 2008

40

Comparative toxicity of oleic and linoleic acid on human lymphocytes

Maria F. Cury-Boaventura, Renata Gorjão, Thaís Martins de Lima, Philip Newsholme, Rui Curi

Journal:

Year:

2006

Language:

english

File:

PDF, 220 KB

english, 2006

41

Effects of varying the type of saturated fatty acid in the rat diet upon serum lipid levels and spleen lymphocyte functions

Nicola M Jeffery, Peter Sanderson, Eric A Newsholme, Philip C Calder

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

42

Activities of some key enzymes of carbohydrate, ketone body, adenosine and glutamine metabolism in liver, and brown and white adipose tissues of the rat

Greg Cooney, Rui Curi, Andrew Mitchelson, Philip Newsholme, Morag Simpson, Eric A. Newsholme

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 256 KB

english, 1986

43

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion

Christophe Broca, Lorraine Brennan, Pierre Petit, Philip Newsholme, Pierre Maechler

Journal:

Year:

2003

Language:

english

File:

PDF, 413 KB

english, 2003

44

The influence of dietary fatty acids on the activity and metabolic control of peroxisomal carnitine palmitoyltransferase in the liver

Glen W. Power, Philip C. Calder, Eric A. Newsholme

Journal:

Nutrition Research

Year:

1997

Language:

english

File:

PDF, 958 KB

english, 1997

45

Differential nitric oxide levels in the blood and skeletal muscle of type 2 diabetic subjects may be consequence of adiposity: a preliminary study

Krause, Mauricio, Rodrigues-Krause, Josianne, O'Hagan, Ciara, De Vito, Giuseppe, Boreham, Colin, Susta, Davide, Newsholme, Philip, Murphy, Colin

Journal:

Year:

2012

Language:

english

File:

PDF, 395 KB

english, 2012

46

Effect of moderate weight loss on prolactin secretion in normal female volunteers

Ian M. Anderson, William S. Crook, Sasha E. Gartside, Mark Parry-Billings, Eric A. Newsholme, Philip J. Cowen

Journal:

Psychiatry Research

Year:

1989

Language:

english

File:

PDF, 538 KB

english, 1989

47

Complement Activation of Electrogenic Ion Transport in Isolated Rat Colon

Declan F McCole, Barbara Otti, Philip Newsholme, Alan W Baird

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 380 KB

english, 1997

48

Corrigendum to “Comparative toxicity of oleic and linoleic acid on human lymphocytes” [Life Sci. 78 (2006) 1448–1456]

Cury-Boaventura, Maria F., Gorjao, Renata, de Lima, Thaís Martins, Newsholme, Philip, Curi, Rui

Journal:

Year:

2014

Language:

english

File:

PDF, 138 KB

english, 2014

49

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

Newsholme, Philip, Homem De Bittencourt, Paulo I., O' Hagan, Ciara, De Vito, Giuseppe, Murphy, Colin, Krause, Mauricio S.

Journal:

Clinical Science

Year:

2009

Language:

english

File:

PDF, 715 KB

english, 2009

50

Ion-Transfer Electrochemistry of Rat Amylin at the Water-Organogel Microinterface Array and Its Selective Detection in a Protein Mixture

Alvarez de Eulate, Eva, O'Sullivan, Shane, Fletcher, Sharon, Newsholme, Philip, Arrigan, Damien W. M.

Journal:

Chemistry – An Asian Journal

Year:

2013

Language:

english

File:

PDF, 526 KB

english, 2013